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In addition to the positive cardiovascular outcomes demonstrated in the studies discussed, early initiation of SGLT-2i is increasingly emphasized to reduce associated complications

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About 60% of GLP-1 users who experience gastrointestinal side effects report that nighttime injection significantly reduces their perception of nausea, simply because they sleep through the worst of it

One of these studies also failed to identify any change in anxiety-like behavior 162 , while two further studies employing exendin-4 observed an anxiogenic effect following acute administration 158,169