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Tumours over 2 cm diameter required a 6-mm excision margin to provide greater than 95% complete histological cure.[44] For high-risk SCC [Table 2], the National Comprehensive Cancer Network (NCCN) guidelines suggest in the absence of MMS or a pathology service able to provide examination of 100% of the excised margin, tumours should be excised with 1 cm margin of normal skin.[45] Radiotherapy Radiotherapy is an effective treatment modality for select patients with NMSC unable to undergo surgery, as efficacy is overall lower than with MMS or SE with predetermined margins