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CHO-K1 cells (ATCC) were stably transfected with a human GLP-1R expression plasmid and maintained in Dulbeccos Modified Eagle Medium, 10% fetal bovine serum, 500 g/mL geneticin and 400 g/mL hygromycin B

A study conducted on rodents has also revealed that GLP-1RAs can exert glucagonotropic effects depending on glucose levels, adding complexity to their role in glucagon regulation (52)

Approximately 20.9% of participants on the 12mg dose experienced dysesthesia, compared to only 0.7% on placebo

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