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The safety data for each compound individually is reassuring, but combination safety requires its own evaluation because pharmacological interactions can produce unexpected results even when each agent is well-characterized on its own

The NAD + decline during normal aging results in oxidative damage, metabolic disorder, circadian rhythm abnormalities, and mitochondrial dysfunction through regulating signaling pathways, such as p53, NF-B, PGC-1 and HIF-1, by sirtuins and PARPs

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The structure allows researchers to do reproducible studies across different experimental conditions