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Phase 2 clinical trial data published in the New England Journal of Medicine in 2023 demonstrated substantial mean reductions in body weight in some participants exceeding 20% over 48 weeks alongside improvements in glycaemic control and cardiometabolic markers

any acceleration of net price declines beyond current guidance would compress the revenue line before volume catches up

But there's a problem hiding inside those results that doesn't get enough attention: not all the weight you're losing is fat

Dexfenfluramine and pergolide cause heart valve disease via valve metabolic reprogramming and ongoing matrix remodeling