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Extended plasma half-life of REW compared to WT was dependent on human FcRn, as the REW substitutions disrupted pH-dependent binding to mouse FcRn, and resulted in about 2-fold shorter plasma half-life in conventional mice (Fig

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Among these alleles, 4 were obtained from lines collected before the use of DDT and so it is unlikely that the G171K change occurred in response to DDT selection

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