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105, 106, 107, 108, 109, 110, 111 Osteosarcomatous metaplasia in a malignant melanoma may be the sequela of an alteration in benign stromal fibroblasts as a host response to the tumor, or it could represent a divergent differentiation pattern, whereby melanoma cells acquire the machinery necessary for the production of malignant osteoid

Tomayko MM, Reynolds CP

To comply: at a minimum, be sure you have an SOP for: Receipt, identification, storage, handling, mixing, and sampling of test and control articles Test system observations Lab tests New method development and validation Specimen identity and collection Histopathology Data integrity, handling, storage and retrieval Maintenance and calibration of equipment If tests involve animals, room preparation animal care, transfer, placement, and identification

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