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Clinical evidence on the involvement of gut-related factors in osteoporosis led us to undertake the core concept of the gutbone axis and systematically summarize that the intestinal intrinsic structure, gut microbiota, and derived metabolites, with the immune and endocrine routes as the intermediate transitions, attain a bidirectional interplay with skeletal tissue through the gutbone axis

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These changes in expression may be due to decreased glutathione and increased oxidative stress

Symptoms of B12 Deficiency B12 deficiency can cause a variety of symptoms, including fatigue, anemia, nerve problems, and memory loss