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Evidence from the same research field indicates that GLP-1 medications, particularly semaglutide, have shown an impact on addiction and substance use disorders

Douat-Casassus, C., Pulka, K., Claudon, P

Research has characterised PT-141 as a direct MT-II derivative produced by C-terminal amide hydrolysis , documenting preserved cyclic heptapeptide structure, maintained MC3R/MC4R pro-sexual activity, and reduced MC1R-mediated pigmentation activity relative to MT-II

This is the beginning and this is interesting, but now we need to replicate these findings." But few experts are ready to get behind widespread off-label use of GLP-1 drugs