Gupta A, Sharma S, Nain CK, Sharma BK, Ganguly NK
Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use
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Ethics declarations Competing interests We disclose the following potential conflicts of interest regarding the publication of this manuscript: This research was partly funded by Cleara Biotech
