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Additionally, a CRISPR suppression screen and ferroptosis-resistant cell line investigation revealed the deactivation of ACSL4 as a critical mechanism for inhibiting ferroptosis in various conditions

BMC Musculoskelet Disord 23:465 Li J, Fu LZ, Liu L, Xie F, Dai RC (2017) Glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide alters bone marrow exosome-mediated miRNA signal pathways in ovariectomized rats with type 2 diabetes

These are associations rather than proof that altering NNMT activity reverses metabolic changes, but they motivate continued research into NNMT inhibitors in metabolic models