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In the normal myometrium, homeostasis is achieved with the assistance of matrix metalloproteinases (MMP), which are involved in remodeling and degrading certain constituents of the extracellular matrices, such as collagen, which contributes to the stiffness of ECM ( In addition, when the UF animal model was being treated with LD the BCL-2 expression in the uterine tissue was significantly decreased with an increase in Bax mRNA expression, thus showing the apoptotic potential of LD in the treatment of UF (Wang et al., 2020)

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