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Preclinical work has reported a distinct selectivity profile, with growth hormone stimulation observed at concentrations that did not trigger ACTH or cortisol secretion, making it a useful tool for isolating growth hormone-specific signalling without activation of the hypothalamic-pituitary-adrenal axis

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However, rapid fat loss can come with unwanted lean-mass reduction (up to 25-39% of total weight loss) as fat-free mass in some trials

For example, statins like atorvastatin and lovastatin may show delayed peak levels, but overall exposure remains unaffected