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This resource is enriched with detailed highlights on selected molecules targeting high-interest areas such as synthetically lethal Pol inhibitors, SARM1 inhibitors for neurodegenerative indications, and our best guess at the identity of Gileads small molecule GLP-1R agonist GS-4571

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With disease progression, iron depletion in oligodendrocytes may impair myelin and, ultimately, axonal integrity in the white matter, which is believed to play a crucial role in chronic progressive MS [189]