Notably, these effective concentrations were 16,000-80,000,000 times lower than concentrations of melatonin required for comparable effects, suggesting highly potent regulatory mechanisms rather than simple antioxidant activity
The recovered COVID-19 group had remarkably decreased tryptophan levels, hyperactive monocytes that are spitting out inflammatory mediators (sCD14/sCD163), high levels of inflammatory lipid byproducts, altered metabolic gene expression, activated inflammasomes, higher caspase-1/4/5 activity and plasma IL-1 levels, increased T-cell activation, and increased oxidative stress
doi: 10.1038/s41392-025-02175-1, 10
Therefore, it is essential to consult with a healthcare professional before starting any new treatment regimen