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PMID: 21477504

Appetite Suppression: Research indicates that MT-II suppresses appetite and promotes fat loss by targeting melanocortin receptors (MC2R and MC5R) involved in lipolysis

Researchers recruited 407 participants with an average age of 56 and body-mass index (BMI) of 40.3 for the study, who received either a 2.4 mg dose of semaglutide once a week or a placebo for 68 weeks

We also analyzed the DIA dataset of the synthetic phosphopeptides using dDIA without a spectral library and found that in this case we needed to apply a higher site confidence score cutoff of 0.99 to achieve error rates comparable to library-based DIA and DDA (Supplementary Fig