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The dominant reasons, documented across multiple 2025 real-world studies, are: cost and insurance denials (47.6% of discontinuations), intolerance of GI side effects (14.6%), and supply shortages (11.8%)

Montessuit C, Thorburn A (1999) Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists

The samples were subsequently reprecipitated with TCA, and a mixture of deuterated IS for every marker was added, including [2H8]Lys (d8-Lys), [2H5]5-hydroxy-2-aminovaleric acid (d5-HAVA), a stable derivative for GSA