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Others do better with something small

As given at ACD/iLabs, LogD niclosamide (for their calculated pKa of 6.89) is 4.55 at pH 0.01 and at pH 7.2 it is still 4.23

It is a 31-amino acid peptide with a molecular weight of approximately 4,113.58 daltons

Disadvantages Disadvantages of UGFS include: 11,12 a higher five-year varicose vein recurrence with sclerotherapy alone compared with combination endovenous laser and sclerotherapy five-year failure rate above 20% for larger diameter veins (greater than 5 mm) potential for gas embolism higher likelihood of matting and hyperpigmentation (hemosiderin staining) longer time (months) for vein reabsorption and disappearance