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It is a melatonin modification originally developed alongside Melanotan 1 peptide at the University of Arizona in the 1980s

When not drinking alcohol, your body releases a hormone called vasopressin (which is also known as the antidiuretic hormone (ADH)) 1 , which tells your kidneys to hold on to water and reabsorb it back into the bloodstream

The peak discomfort window is typically **1248 hours post-injection**, though some patients especially during dose escalation feel it for up to 72 hours ([FDA Wegovy Prescribing Information]( Nausea is most intense during the early weeks of treatment and during each dose increase

The key is to have an open and thorough discussion with your doctor about finding the safest and most effective path forward for you