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As of current guidelines, GLP-1 receptor agonists including tirzepatide are not listed as disqualifying medications, though donors are advised to discuss their complete medical history with collection staff

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One human study found that, on average, 500 milligrams of berberine, taken orally for 12 weeks, produced a 2.3% reduction in weight

Glycemic markers respond reliably to therapy, with semaglutide tested across 300 clinical trials and 90% showing improved glucose regulation, so falling fasting glucose and HbA1c usually indicate therapeutic effect rather than assay interference