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To establish the importance of the NEP-derived metabolite GLP-1(2836) to the overall cardiovascular biology of GLP-1, we used sacubitril, a pharmacological inhibitor of NEP, and assessed in vitro cAMP accumulation in caSMCs, as well as functional LVDP recovery in an ex vivo Langendorff model of IRI

Pfizer's experience suggests it is a chemotype-dependent problem, not a class problem

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Specialist weight management services may prescribe higher-dose semaglutide (Wegovy) for adults with a BMI 35 kg/m (or 30 kg/m in exceptional cases) and at least one weight-related comorbidity