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Osmotic vs stimulant laxatives (OTC options) First-line pharmacologic option: Polyethylene glycol (PEG 3350) is recommended by gastroenterology guidelines because it increases stool water content, improves stool frequency, and is generally well tolerated for ongoing use. Alternative osmotic option: Magnesium oxide may help some patients and is conditionally recommended in gastroenterology society guidance

Although rare, additional neurologic sequelae have been documented, including cerebellar ataxia and meningoencephalitis

Cardiovascular disease and hair cortisol: A novel biomarker of chronic stress

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