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In a randomized, double-blind, placebo-controlled trial of 100 patients with episodic migraine and DAO deficiency, DAO supplementation before meals modestly reduced the mean duration of migraine attacks.59 The authors concluded that one month of DAO supplementation showed a positive trend, while calling for longer and larger studies

Yiangou, Andreas

The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion