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These activators increase the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) and ATP-binding cassette transporter subfamily G member 1 (ABCG1) in peritoneal macrophages, as well as scavenger receptor class B member 1 (SR-BI) and lecithin-cholesterol acyltransferase (LCAT) expression in the liver of apoE / mice, thereby reducing inflammatory cytokine production (tumor necrosis factor , monocyte chemoattractant protein-1, andinterleukin-6) and atherosclerotic plaque formation [12]

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Nature 420 , 629635 (2002)