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Our present findings are consistent with, and extend, a growing body of evidence for the broad role of the OB as a key metabolic hub able to both detect and control variations of insulin and glucose 33

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One week after the injection, all animals were transcardially perfused with phosphate-buffered saline (PBS) 1X (pH 7.4) followed by ice-cold 4% paraformaldehyde (PFA

(2) confirmed that, as expected, the semaglutide treatment groups (with and without concomitant -MSTN/-ActA) involved similar decreases in caloric intake (Supplementary Fig