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CRLs can be broken down into five broad subfamilies that collectively contain hundreds of substrate receptors, which are the targets of the E3 ligands commonly used in PROTACs 7

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Clinically, Epi_2 tumors are associated with lymph-node metastasis and refractoriness to both immune-checkpoint blockade and anti-EGFR therapies ( Collectively, cuproptosis constitutes a tripartite regulatory circuittumor suppression, immune modulation, and drug sensitivityin OSCC