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Also, optogenetic stimulation of parvalbumin interneurons at 40 Hz restores hippocampal slow gamma oscillations amplitude, and phase-amplitude coupling of the J20 AD mouse model, resulting in the rescue of spatial memory in mice despite significant plaque deposition ( Discussion The exact cellular mechanisms at the root of plasticity changes during brain development in the course of the progression of aberrant network activity leading to cognitive dysfunction in AD remain elusive

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Recent findings emphasize the dying cell-macrophage interface as a modulator of macrophage functional heterogeneity

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