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Glucose-dependent insulinotropic polypeptide (GIP) receptor agonists In addition to being a GLP-1 RA, tirzepatide is also an agonist of GIP, a gut hormone that impacts glucose and fat metabolism.13 Its similar to GLP-1 in that it stimulates insulin secretion from the pancreas, and research shows that the two hormones work synergistically to increase weight loss

The cutoff value of H -score was determined as the largest Youden index after analyzing the ROC curve (68.5) (Figure 1D)

Sermorelin is FDA-approved for pediatric GH deficiency only

Both alcohol and tobacco introduce oxidative stress, which can deplete glutathione reserves