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GoF receptors are often characterised by a greater propensity for G protein versus -arrestin recruitment and signalling, slower rate of receptor internalisation and rapid recycling back to the plasma membrane, with these characteristics being independent of their surface expression levels (Liu et al., 2022)

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CrossRef Toxic lipid-induced epigenetic activation of ICAM1 in liver sinusoidal endothelium regulates myeloid-driven fibro-inflammatory response in MASH Qianqian Guo, Nantawat Satthawiwat, Akitoshi Sano, Chady Meroueh, Asma Hamdi, Xin Dai, Khaled Warasnhe, Alexander M

The origins and specifications of the mice used in this study are detailed in the Supplemental Methods