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(2) enhanced aromatase activity in adipose tissue, leading to increased local and systemic estrogen levels, thereby stimulating pituitary prolactinocytes to synthesize and secrete prolactin

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Similarly, we previously reported that only pulsatile GH administration in humans increased the rate of lipolysis [10], while plasma levels of IGF-1, reflecting its hepatic production, as well as muscle IGF-1 mRNA levels are controlled primarily by the interpulse, nadir, GH concentrations [9, 10]