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Mechanistically, the role of KHK in alcohol preference is most likely due to the role of fructose metabolism in the activity levels of aldehyde dehydrogenase (ALDH), the mitochondrial enzyme that metabolizes the toxic intermediate in ethanol metabolism, acetaldehyde
C.HuntJ.PerinI.RuckenbauerP.Workshop on trichothecenes with a focus on DON: Summary reportToxicol
Both K176 and K307 participate in salt bridge interactions with the opposing subunit, and acetylation of these sites will weaken or eliminate key interactions that stabilize the TrxR1 tetramers
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