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Blocking the transmission of the HGF/c-MET pathway in CAFs has been demonstrated to impede the movement of CRC cells driven by RAB31 expression, highlighting the role of CAFs in enhancing paracrine HGF release and stimulating the HGF/c-MET pathway, which in turn propels tumor growth [48]

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Glutathione, GSH, Glutathione-SH31 [2] 5 mMGSSG, Glutathione-S-S-Glutathione [3] 0.510 mM1/1001/1000 (GSH) (glutathione disulfide, GSSG)298%GSH [] (L--glutamyl-L-cysteinyl-glycine)---- [] 2 2 [] 1NADPH: GSSG + 2 e 2 GSH: 240 mV [4] ) S-(S-)S- (H2O2)(S-)S- 2 -()2 [] -S- (GSTs) I II D- [] [] -2---- [] --- [] --2- [5] [] [] 2016 (RCT) 2RCT1 [6] [] (5-) () [7] [] (phorone) (glutathione depletor) [8] [9] [10] 10201488 [11] [] [] Merck Index , 11th Edition, 4369