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Unlike vitamin C, which is water-soluble and clears within hours, or NAC, which supports endogenous synthesis rather than providing the active molecule, glutathione has a tissue half-life of 24 days and a measurable lag before oxidative markers rebound

Trials in HIV patients showed 15 to 20 percent reductions in visceral fat over 26 weeks, with modest overall weight change

p for interaction = 0.91) suggests a similar magnitude of benefit for the primary outcome in this trial based on presence or absence of comorbid CVD on a background of renal impairment (88)