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It has been shown that pro-survival MOMP-inhibiting Bcl-XL is essential to protect reticulocytes from apoptosis and that its loss results in severe impairment of erythropoiesis and anemia development [113]

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10.1002/jcp.27042 42 GugiattiE.TencaC.RaveraS.FabbiM.GhiottoF.MazzarelloA

There have also been reports of clearance followed by recurrence in an additional 3 patients.79 Little evidence supports the use of 5-fluorouracil to treat LM in clinical practice.1,79,150 Retinoids Retinoids have been used to treat LM due to their ability to inhibit the proliferation and induce the differentiation of murine melanocytes in cultures