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In agreement with the noncompetitive behavior of 9 and as determined by structural superposition of the cryo-EM structure and the X-ray NADPH-TGR- complex 17 , inhibitor 9 does not sterically interfere with NADPH binding

The addition of oligomycin, an inhibitor of mitochondrial ATP synthesis, allowed us to analyze ATP-linked respiration and the proton leak across the inner membrane (Fig

Acta Biomater 4:1116

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