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J Mol Biol (2009) 386:126577

Double the intended dose

Patients with HFpEF were defined as follows: 1) patients with symptoms and signs of HF as defined by the Framingham criteria, 2) patients with a left ventricular ejection fraction 45% as previously described (6) (7), and 3) patients without HF aetiologies of severe valve disease, congenital disease, complete atrial ventricular block, sick sinus syndrome, pericardial disease, primary pulmonary hypertension, pulmonary artery embolism, and acute myocardial infarction