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Coupled with their high molecular weight and high polarity, it is usually difficult to penetrate the gastrointestinal epithelial cell membrane, resulting in low oral bioavailability

Both medications carry similar gastrointestinal side effect profiles

29 Los iSGLT2 eliminan 60-80 gramos de glucosa al da por orina y este efecto es independiente de la funcin de la clula beta y del tiempo de evolucin de la diabetes mellitus tipo 2, por lo que pueden prescribirse en cualquier momento de la enfermedad (Figura 2)

This work was supported by the National Key R&D Program of China (2022YFA1103900 to Fuming L.), the National Natural Science Foundation of China (82273223 to Fuming L