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10.3389/fphar.2021.751380 Summary Keywords trimethylamine oxide, heart failure, chronic kidney disease, cardiorenal syndrome, trimethylamine Citation Zhang J, Zhu P, Li S, Gao Y and Xing Y (2023) From heart failure and kidney dysfunction to cardiorenal syndrome: TMAO may be a bridge

[DOI] [PubMed] [Google Scholar] 162.Han L., Zhang X.-Y., Wang Y.-L., Li X., Yang X.-H., Huang M., Hu K., Li L.-H., Wei Y

The muscle (skeletal muscle) is crucial in maintaining ROS below a threshold level to keep up redox homeostasis

This result suggested that cystine starvation may induce ferroptosis by both blocking GSH biosynthesis and reducing GPX4 protein level