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Okerson T, Yan P, Stonehouse A, et al

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Common clinical manifestations of the disease include generalized dystonia, which can lead to complications such as speech disorders, mobility disorders and the occurrence of dysphagia, bradykinesia, macrocephaly, and seizures, etc

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We examined potential small-study effects using a comparison-adjusted funnel plot for the primary outcome of percent change in body weight from baseline

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