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Stress and environmental toxins also play a role in triggering or worsening the condition

Hospitalization may be required for persistent vomiting, significant hypoglycemia, or complications such as pancreatitis

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notably described that the substitution of the first 290 residues of MRP1 by the corresponding residues of MRP2, like in chimera M1, leads to a complete absence of addressing to the plasma membrane with a retention in the endoplasmic reticulum 19