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May extend shelf life to: 45-60 days depending on formulation Pharmacy should provide specific expiration guidance If unsure: Follow standard 28-30 day rule

Psychiatric conditions, especially mood disorders, frequently coexist with nociplastic pain, suggesting a bidirectional relationship due to shared risk factors like trauma and common disease mechanisms involving neurotransmitters

Remember that consistency is key, and the most effective approach combines multiple strategies rather than relying on any single intervention