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The TRIUMPH-4 Phase 3 data revealed a new safety signal: dysesthesia

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Subgroup analysis indicated that homozygous mutations were associated with more severe impairment of long-term weight loss than heterozygous mutations, which explains why bi-allelic MC4R mutation carriers have poorer long-term outcomes than heterozygous carriers

What used to be a careful discussion between patient and doctor is now often handled through marketing funnels and online platforms