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Gastrointestinal side effects from semaglutidenausea, constipation, or diarrheamay be slightly more noticeable when combined with metformin, since metformin itself can cause digestive changes

Additionally, many individuals describe a subjective sensation of feeling mentally slow, fuzzy, or spaced out, which significantly impairs their ability to think clearly or concentrate [9]

Researchers should note that none of these analogs, including sermorelin, has been tested for longer than 16 weeks

Discussion This study adds to the limited available data on the use of semaglutide in patients with advanced CKD and provides insight over a prolonged follow-up period exceeding three years (median 1,187 days [IQR 6021,442]), with the majority of patients receiving maintenance hemodialysis (58.8%)