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But human metabolism is different from that of rodents

A recent study in colon cancer cells by Pathi et al, 2012 demonstrated that aspirin caused caspase-dependent proteolysis of Sp1, Sp3 and Sp4 (specificity protein) transcription factors, which was associated with downregulation of several Sp-regulated genes involved in cell survival, proliferation and angiogenesis

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SUBCELLULAR LOCALIZATION ANALYSIS For the construction of the fusion gene constructs of 35S pro :As GGT1 N100 :GFP , 35S pro :AsGGT2 N100 :GFP , and 35S pro :AsGGT3 N100 :GFP , partial coding regions of AsGGT1 , AsGGT2 , and AsGGT3 that encode the N-terminal 100 amino acid residues were amplified by PCR using KOD plus DNA polymerase (Toyobo) and the following gene-specific primers: AsGGT1-FSal (5- GTCGAC ATGAACCAAATGGCGCCGGCTTCTTC-3) and AsGGT1-N100-RNco (5- CCATGG AACCACCACCACCACC ACCTTTTCTCAGAACTGAAGCTCC-3) for AsGGT1