The adverse reactions described in Table 1 below are based on data from an eight week cross over trial in which vitamin B12 deficient patients in hematologic remission received one vitamin B12 intramuscular injection (N=25) and then received once weekly intranasal administration of another nasal cyanocobalamin formulation (N=24) for 4 weeks
[95] [19] [96] The amount of cyanide in cyanocobalamin is generally not considered a health risk, since even in a 1,000 g dose, the 20 g of cyanide it contains is less than the daily consumption of cyanide from food
For the annual burden, we added the labor category for Chief Executives in response to comments on the CY 2026 OPPS/ASC proposed rule, and we now estimate a total of 415,296 hours for all hospitals (7,416 hospitals 56 hours) at a cost of $40,269,176.60 (7,416 hospitals [($128/hour 2 hours) + ($87.52/hour 40 hours) + ($97.30/hour 12 hours) + ($252.82/hour 2 hours]), to include the burden for the senior hospital official
B12 rich foods include animal organ meats, eggs and dairy products
