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In addition, the composition of multiple constituents of Pycnogenol , each having different benefits for human health, further explains its broad clinical application ( For the first time, this review aims to systematically summarize and discuss these gold standard RDP trials comparing the efficacy of Pycnogenol to placebo and giving explanations for the different effects with the help of the respective mechanisms of action

The oxidative milieu not only damages cellular components but also sensitizes hepatic tissue to inflammatory stimuli, fostering activation of Kupffer cells and the release of proinflammatory cytokines such as TNF-, IL-6, and IL-1

Dec 2019;12(12):e201900102

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