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Hotaling, A
Writing in Acta Pharmaceutica Sinica B, researchers explained how this could seriously affect intestinal function, increasing obstruction risk: 24 "Because GLP-1RAs could cause continuous increases in the intestinal length and villus height, the small intestine may become as inelastic and fibrotic as a loose spring, leading to long-term upper intestinal obstruction ..." To date, clinical trials havent revealed such changes in the human gut, likely because its difficult to measure small intestine length
10.1038/nmeth.1322 50 WolfE.GaquerelE.ScharmannM.YantL.KochM
The dose escalation phase alone takes 16 to 20 weeks for most GLP-1 medications, and meaningful weight loss really begins at therapeutic doses
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