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Binding of -MSH to MC4R triggers a Gs protein-coupled signaling cascade, which increases intracellular cyclic AMP (cAMP) levels and ultimately activates downstream pathways that promote satiety and increase energy expenditure [9]

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Proc Natl Acad Sci U S A (2014) 111(8):306873.10.1073/pnas.1316925111 33 LiJWangHMasonJMLevineJYuMUlloaLet alRecombinant HMGB1 with cytokine-stimulating activity