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Drugs that increase acetaminophen toxicity: INH

Compounded medications are not reviewed or approved by the FDA for safety or effectiveness in the same manner as commercially available drugs

Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states