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Notably, combinatorial treatment with CB-839 and mTOR inhibitors has shown synergistic effects in preclinical studies, offering a compelling rationale for dual-targeted strategies and highlighting their potential for future clinical translation (253, 254)

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Physiological Reviews 59, 527-605CrossRefGoogle ScholarPubMed 2Palmer, R.M.J., Rees, D.D., Ashton, D.S

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